Single-use anion exchange chromatography

The goal of new bioprocessing strategies is to increase the biopharmaceutical process robustness and to reduce its cost. Here we explore the effects of implementing such new strategies, enabled by novel 3M solutions, on the cost of mAb manufacturing process using modelling. Specifically, we look at the implementation of high precision chromatographic clarification using a high-performance single-use 3M Polisher ST AEX polishing solutions.

Advancements in downstream processing are necessary to remove purification bottlenecks, for streamlining development and reducing cost, complexity, and risks associated with biopharmaceutical production. Innovation in functional chemistries and materials science create opportunities for technology suppliers to integrate upstream and downstream unit operations with membrane chromatography solutions.

Learn about novel bioprocessing technologies in the biomanufacturing space that are in development for existing downstream processes.

How lower overall costs and facility fit as e2e solutions facilitate greater implementation.

Join us as we explore how novel bioprocessing solutions, based on advanced materials and ligand chemistries, enable new bioprocessing strategies that address critical challenges in process simplification and intensification. Specifically, we demonstrate how implementing chromatographic separation at clarification enables single stage, scalable, and efficient harvesting unit operation. Additionally, we show that a combination of novel ligand chemistry and non-woven support technologies, enable effective transition of the polisher AEX unit operation to a single use solution, using 3M Polisher ST.