3M™ Emphaze™ AEX Series Hybrid Purifier BV120, EMP513AEX020A, Scale-Up, 1/Case

Emphaze™ AEX Hybrid Purifier is an all-synthetic, multi-mechanism clarifying device which contains a Q-functional anion exchange media and a fine particle and bioburden reduction membrane.

Emphaze™ AEX Hybrid Purifier optimizes clarification of mammalian cell cultures and optimizes downstream monoclonal antibody (mAb) purification process by protecting the protein A column, increasing product purity and life of protein A column. Emphaze™ AEX Hybrid Purifier is an all-synthetic, multi-mechanism clarifying single-use device containing a multi-mechanism all synthetic Q-functional anion exchange media integrated with a fine particle, bioburden reduction membrane. The anion exchange media is comprised of a quaternary amine hydrogel supported by a fine fiber nonwoven scaffold. A combination of 3M technology platforms enables the hyperfunctionalization of a high purity polypropylene nonwoven with a covalently attached, thermally stable, water soluble polymer; the functional polymer accounts for roughly two-thirds of the mass of the anion exchange media. The bioburden reduction membrane is a highly asymmetric, high loading capacity polyamide membrane which has nine zones of decreasing pore size spanning a roughly 20X range and terminating with a 0.2 µm bioburden reduction rated pore size.